Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC?? = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC?? = 10 to 100 nM).

Ac-DEVD-CHO是聚(adp -核糖)聚合酶(PARP)被caspase-3裂解的有效抑制劑(IC??= 0.2 nM)。PARP的分裂發(fā)生在細胞凋亡的開始。肽醛能夠在體外減弱凋亡事件(IC??= 10至100 nM)。

編號:194344

中文名稱:半胱胺酸蛋白酶-10：Ac-Asp-Glu-Val-Asp-CHO

英文名:PASE-3 Inhibitor I; Ac-Asp-Glu-Val-Asp-CHO

CAS號:184179-08-6

單字母:Ac-DEVD-CHO

三字母:Ac-Asp-Glu-Val-Asp-CHO

氨基酸個數(shù):4

分子式:C20H30O11N4

平均分子量:502.47

精確分子量:502.19

等電點(PI):-

pH=7.0時的凈電荷數(shù):-3

平均親水性:1.875

疏水性值:-1.58

來源:化學(xué)合成

鹽體系:TFA鹽

儲存條件:-20攝氏度

標(biāo)簽:<span class="nolink">醛肽<span class="nolink">抑制劑相關(guān)肽

參考文獻：

10.1080/10428190701385181The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines

10.1016/j.jdermsci.2007.06.008Flavonolignans from Silybum marianum moderate UVA-induced oxidative damage to HaCaT keratinocytes

10.1002/cbdv.200800354Antiproliferative and proapoptotic activities of a new class of pyrazole derivatives in HL-60 cells