英文名：BK-1361，cyclo(RLsKDK)

CAS：1975145-82-4

密度： 1.46±0.1 g/cm3(Predicted)

酸度系數(shù)(pKa)：4.01±0.10(Predicted)

1.Molecular formula：C31H57N11O9

2.Molecular weight：727.865

3.Packaging specification：1g、5g、10g, flexible packaging, including 100mg packaging and 500mg 1g and 5g large packaging

Product structure：

二、Reaction characteristics：

BK-1361（BK1361，cyclo-RLsKDK）是一種具有RLsKDK（s=D-絲氨酸）的環(huán)肽，其作為ADAM8的有效選擇性抑制劑起作用，IC50為120nM，對(duì)ADAM 9,10,12沒有顯示出顯著活性。在基于細(xì)胞的脫落測定中抑制CD23的脫落，IC50為182nM。?

BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM; inhibit shedding of CD23 with IC50 of 182 nM in cell-based shedding assays, reduces migration/invasion of pancreatic cancer cells and less ERK1/2 and MMP activation, causes change in cell morphology; decreases tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in Kras(G12D)-driven mouse model of PDAC.

三、Matters for use：

It is sensitive to light and temperature. In order to use the reagent effectively, the material should always be kept in a low temperature dry condition, away from light, and avoid frequent thawing and freezing.

四、storage conditions:

Store at - 20 ℃ as much as possible. If conditions permit, the material can be treated under inert gas to obtain better stability of the reagent.

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（上述信息均由陜西新研博美生物科技有限公司的小編木木所整理）