紫杉醇(Paclitaxel),微管穩(wěn)定劑 是從紫杉中提取的具有抗腫瘤活性的化合物。 紫杉醇與微管蛋白結合并抑制微管的分解，從而導致細胞分裂的抑制。 該產(chǎn)品還通過與凋亡抑制蛋白Bcl-2（B細胞白血病2）結合并阻斷其功能來誘導凋亡。

溶解度:SolubilitySoluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water.

性狀：固體粉末

儲藏條件：儲存溫度2-8°C

案例：

Intrinsic paclitaxel resistance in the mesenchymal-like subset. (a) Ecad-hi and Ecad-lo sub-populations of SCC9/OCTT2 cells were treated with paclitaxel for 4 h. Drug-induced growth inhibition is shown 72 h later by MTT assay. (b) SCC9 cells were exposed to 100 nM paclitaxel for 4 h. After 72 h, the percentage of Ecad-lo cells among total viable cells pre versus. post-drug treatment is compared by FC (left and second panel). Cells surviving paclitaxel were sorted into Ecad-hi and Ecad-lo subsets and analyzed for vimentin expression (third panel). The percentage of Ecad-lo cells present after 48 continuous hours of paclitaxel exposure was also measured (right panel). (c) The same subsets treated with paclitaxel for 4 h were compared against untreated controls for clonogenicity (left) and total growth after 72 h (right) by MTT. (d) SCC9 cells treated with 100 nM paclitaxel or dimethylsulfoxide control for 4 h were observed by video microscopy in the presence of propidium iodide. Representative still images at 0, 24 and 48 h ( × 20) after treatment identify cell death with propidium iodide uptake (red). Yellow lines encompass areas of mesenenchymal-like morphology. Data in (a–c) are representative of three independent experiments.